However, after transfection of DLGAP4-flag into the HCC cell line MHCC97h, the expression levels of PPARβ/δ, N-cadherin and cyclin D1 were significantly increased, while the expression of E-cadherin was significantly decreased compared with that in the vector-flag group (Supplementary Fig. 3). The gene discussed is CDH2; the disease is hepatocellular carcinoma.