This stood in sharp contrast to the likely passenger genes TTN, PCLO, DNAH7 and MUC176 for which the cohort mutation distribution was in close agreement with the simulated neutral outcomes (Fig. 2a; q > 0.97), with strong aggregation of mutated cases in the high-burden range and near-absence among low-burden tumours (Fig. 2b). The gene discussed is PCLO; the disease is neoplasm.