For example, we found a signature with top genes CXCR4, which plays a role in normal plasma cell development and has also been implicated in MM progression43,44, and RGS1 and RGS2, which are regulators of G Protein signaling that may regulate the CXCR4-CXCL12 axis45. Here, CXCL12 is linked to Miyoshi myopathy.