CLDN2 and Peritoneal Fibrosis: On the other hand, other miRNAs were demonstrated to promote peritoneal fibrosis: miR-199a/214 Cluster targeting E-cadherin and Claudin-2 promoted high glucose-induced peritoneal fibrosis [31]; miR-145 promoted MMT during the development of peritoneal fibrosis by suppressing FGF10 activity [32], miR-21 promoted fibrogenesis during PD [33].