Bupropion also blocks the reuptake of noradrenaline, with downstream modulation of tumour necrosis factor alpha and upregulation of brain-derived neurotrophic factor (BDNF) in MDD, which may be an alternative intra- and extracellular mechanism by which it exerts its antidepressant and cognitive effects [90, 91]. This evidence concerns the gene BDNF and major depressive disorder.