Regarding in vivo studies, the knockout of ABCA1/G1 enhances macrophage inflammatory responses (7, 8, 9), and the tissue-specific knockout of ABCA1/G1 or ABCA1 has characteristic effects, including autoimmune activation in dendritic cells (10), impaired diet-induced obesity in adipose tissue (11), and less phagocytosis in astrocytes (12). The gene discussed is ABCA1; the disease is obesity disorder.