TMBIM4 and Stroke: The selective S1R agonist PRE-084 (2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate) [14] can regulate cytokine production in stroke [15], reduce microglial activation in traumatic brain injury, and exert a protective effect in neurogenic inflammation [16] and endothelial barrier damage [17].