Although to date we are not aware of any literature describing an association between mutations in this gene and emphysema or chronic bronchitis, a previous study suggest that a reduced concentration of REV1 transcripts was related with a significant decrease in the diversity of carcinogen-induced lung cancers and complete suppression of tumor development in 27% of the carcinogen-exposed mice models [34]. The gene discussed is REV1; the disease is pulmonary emphysema.