HHAT and respiratory system disorder: For “Transport type for commuting to job workplace: Car or motor vehicle” (that has a causal effect on “Diseases of the respiratory system” and “Other pulmonary diagnosis”) the most statistically significant pathway is the one involving "HHAT G278V non-palmitoyl Hh-Np," p value = 0.008, gene involved: hedgehog acyltransferase (HHAT, related to rs12410877, an intronic variant [17].