The PheWAS performed in the group of self-reported Whites who received less anesthesia showed an association between the rs1799971 in OPRM1 and gingival and periodontal diseases (phecode 523) as well as with periodontitis (acute or chronic) (phecode 523.3), the later providing a protective effect toward the phenotype (odds ratio = 0.17, 95% confidence interval 0.05–0.42, p = 0.0008) (Table 4 and Fig 2). Here, OPRM1 is linked to periodontitis.