CST3 and chronic kidney disease: Consequently, kidney fibrosis and kidney function, assessed by trichrome staining, urine albumin-to-creatinine ratio (ACR), blood urea nitrogen (BUN), and serum cystatin C, were improved in Fth1LysM+/– CKD mice compared with Fth1LysM–/– CKD mice (Figure 2, E and F).