To better understand the pathogenic role of an altered kidney macrophage LIP versus ferritin-stored iron in kidney fibrosis, we next examined the effect of FtH suppression in macrophages by inducing CKD in myeloid specific Fth1-knockout mice (Fth1LysM+/–) (Figure 2 and Supplemental Figures 4–6). The gene discussed is FTH1; the disease is chronic kidney disease.