PQ also increases blood glucose levels becauseof hypoinsulinemia,11 supporting our results.Besides, PQ was shown to increase BACE1 protein levels in the mousecortex,2 supporting our findings, but todecrease p-GSK3β (Tyr216) protein levels in rat hippocampus,17 which indicates GSK3β activation and increasedactivity. This evidence concerns the gene GSK3B and Hypoinsulinemia.