From the foregoing discussion, the promising strategies to enhance collateral flow following ischemic stroke include heme-free sGC activators, Sanguinate, remote ischemic perconditioning, Fasudil, S1P agonists, and stimulation of sphenopalatine ganglion (see Table 1 for a summary of outcome measures). The gene discussed is SGCB; the disease is ischemic stroke.