SLC7A5 and breast cancer: We have applied an integrated approachconsisting of experimental cis-inhibition and uptakestudies with a wild-type MCF-7 human breast cancer cell line, state-of-the-artFlp-In-HEK293-hLAT1/4F2hc-transfected cell line (hereafter HEK-hLAT1),and computational induced-fit docking (IFD) based on the recent cryo-electronmicroscopy (cryo-EM) structure of LAT1.20 Thus, we aim to understand how the electronic and spatial characteristicsof a drug conjugated to phenylalanine will affect the compound’sinteractions with LAT1.