Nearly 30 years ago, we described a large cohort of individuals with severe short stature due to congenital IGHD caused by the homozygous c.57+1G>A mutation in the GHRH receptor (GHRHR) gene (GHRHR OMIM n.618157), with most residing in the city Itabaianinha located just 60 km (37 miles) from Santa Luzia do Itanhy (21), Souza Leite's hometown. This evidence concerns the gene GHRHR and isolated congenital growth hormone deficiency.