From our qRT-PCR based result, it is evident that lower DNMT1 gene expression is prevalent in NTD affected babies when compared to their respective mothers, which is in contrast with the fact that levels of DNMT1 stay at comparative level in both normal embryo and adult blood (data procured from SCREEN interface of ENCODE, Supplementary Figure S3) [33]. The gene discussed is DNMT1; the disease is neural tube defect.