Given that SRSF11 promotes the production of HSPA12A‐Ex2+ transcript and that knockdown of HSPA12A‐Ex2+ significantly inhibits CRC cell migration and invasion, we hypothesize that SRSF11 can influence CRC migration and invasion by increasing the splicing of HSPA12A‐Ex2+ transcripts. Here, HSPA12A is linked to colorectal carcinoma.