identified microRNAs targeting key regulators of the circadian rhythm like SIRT1 (hsa‐miR‐291‐3p and hsa‐miR‐181a‐5p), PER2 (hsa‐miR‐28‐5p) and PER3 (hsa‐miR‐29a‐3p and has‐miR‐181b‐5p) in the context of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).171. This evidence concerns the gene PER3 and myalgic encephalomeyelitis/chronic fatigue syndrome.