In normal thyroid tissues, where the TERT gene is transcriptionally silent, there exist hypomethylated UTSS and TSS or proximal TERT promoter regions, whereas TERT‐expressing PTC and FTC cell lines exhibit hypomethylated proximal promoter but hypermethylated UTSS (Figure 2B).35, 36. The gene discussed is TERT; the disease is thyroid cancer, nonmedullary, 2.