Disruption of circadian rhythm leads to metabolic dysfunctions associated with aging,[22] obesity,[23] adipocyte hypertrophy, and compromised adipose tissue integrity.[24] To explore the possibility that circadian disruption impacts PPARγ acetylation, we adopted a shiftwork mouse model [25] (Figure 1e). Here, PPARG is linked to obesity due to melanocortin 4 receptor deficiency.