PPARγ deacetylation selectively regulates downstream targets, among which is adipsin,[19, 20] a representative adipokine that correlates with obesity, aging, and type 2 diabetes in humans.[30] We observed an increase of adipsin proteins in both the eWAT and BAT of DIO aKQ mice (Figure 6a,b). This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.