Accumulated evidence indicates that both the MAPK and PI3K‐AKT–mTOR pathways contribute to HCM in RASopathies (Gelb, Roberts, & Tartaglia, 2015), and depending upon the cellular context, NS‐causing MRAS mutants differentially impact MAPK and PI3K‐AKT signaling cascades (Motta, Sagi‐Dain, et al., 2020). This evidence concerns the gene AKT1 and RASopathy.