The three affected residues, Gly23, Thr68, and Gln71, are highly conserved in all RAS orthologs and paralogs; they have a crucial role in the catalytic activity of the GTPase, and the corresponding codons (Gly13, Thr58, and Gln61 in H/K/NRAS) are well known hotspots for cancer‐associated and/or RASopathy‐causing mutations in other RAS proteins (Motta, Sagi‐Dain, et al., 2020). This evidence concerns the gene NRAS and cancer.