Subsequent studies further expanded the contribution of somatic PTPN11 mutations in malignancies (Loh et al., 2004; Tartaglia et al., 2004, 2005), demonstrating their specific relevance in the context of childhood neoplasias (Bentires‐Alj et al., 2004; Hugues et al., 2005; Johan et al., 2004; Loh et al., 2005; Watkins, Fidler, Boultwood, & Wainscoat, 2004). Here, PTPN11 is linked to neoplasm.