In 2001, PTPN11 (MIM: 176876), encoding SHP2, a non‐receptor protein tyrosine phosphatase having a relevant role in intracellular signaling and various developmental processes (Tajan, de Rocca Serra, Valet, Edouard, & Yart, 2015; Tartaglia & Gelb, 2005), was identified as the major Noonan syndrome (NS, MIM: PS163950) disease gene using a positional candidacy approach (Tartaglia et al., 2001). Here, PTPN11 is linked to Noonan syndrome.