SHBG and chronic kidney disease: In addition, although total testosterone and free testosterone are highly correlated, this correlation may diverge in individuals with altered hormone binding protein concentrations [sex hormone‐binding globulin (SHBG; binds to testosterone with high affinity) and human serum albumin (binds testosterone with lower affinity than SHBG does)], such as patients with CKD (Goldman et al., 2017).