It has also been reported that ASPN secreted by cancer-associated fibroblasts can promote cancer cell invasion and metastasis (Simkova D.et al., 2016; Castellana B.et al., 2012; Maris P.et al., 2015; Hurley PJ.et al., 2016; Wang L.et al., 2017; Huo W.et al., 2016). This evidence concerns the gene ASPN and cancer.