ASPN and keloid: Due to the rapid development of mechanical biology and the research on the formation and progress of keloids promoted by mechanical forces, the ECM molecular ASPN can also become an effective therapeutic target (Huang C et al., 2012a; Huang C et al., 2012b; Huang C et al., 2013; Deng Z et al., 2021; Syed F et al., 2012).