As an effective inducer of ferroptosis, erastin downregulates GPX4 and upregulates the expression of acyl-coA synthetase long chain family member 4 (ACSL4) to promote ferroptosis in endothelial cells during atherosclerosis, while miR-17-92 protects endothelial cells from ferroptosis induced by erastin by targeting the A20-ACSL4 axis [21]. Here, ACSL4 is linked to atherosclerosis.