Several disease-associated DDX3X mutations are more prone to triggering spontaneous SGs than wild-type DDX3X, and it is thought that this contributes to disease pathophysiology in medulloblastoma and neurodevelopmental delay (DDX3X syndrome) (Valentin-Vega et al., 2016; Lennox et al., 2020). Here, DDX3X is linked to medulloblastoma.