Since previous studies have suggested that Tau may function in neurite outgrowth and growth cone motility and that inactivation of Tau in whole DRG neurons resulted in reduced neurite number and length (Liu, Lee and Jay, 1999), we postulated that the abnormal neurite morphology observed in Elp1 KD neuroblastoma cells might arise from Tau depletion. The gene discussed is MAPT; the disease is neuroblastoma.