To directly investigate this hypothesis, we performed live imaging HCA neurites morphological experiments (similar as shown in Figure 1) using three established Tau-knock down (Tau KD) neuroblastoma cells that express constitutively each one of three distinct Tau shRNAs and respective cell line control, obtained as a kind gift from Paganetti’s lab that were generated as described by them (Sola et al., 2020). The gene discussed is MAPT; the disease is neuroblastoma.