Under Elongator deficiency in Elp1KD neuroblastoma cells, due to Acly instability, the reduced amount of available acetyl-CoA, that donates the acetate group needed for proteins acetylation, results in hypoacetylation of alpha-tubulin and Tau (which might affect also other protein targets) and their concomitant instability which has a direct profound impact in neurite morphology and vesicular transport as described previously (Even et al., 2021) (see Figure 9). This evidence concerns the gene MAPT and neuroblastoma.