WNT1 and metastatic neoplasm: In addition, when we extended our study to the analysis of breast primary tumors using the public TCGA database, we were able to confirm that the hypermethylation of WNT1 is a frequent event in early and advanced LBBC, suggesting that the epigenetic deregulation of WNT1 is not a specific biomarker of metastatic disease but rather a biomarker of breast cancer cells.