In addition, BK channels predominantly expressed in the spinal cord could generate a protective effect on acute and chronic spinal cord injury (SCI) by improving neuronal functions (Ye et al., 2012; Jacobsen et al., 2018), and the BK channel agonist, isopimaric acid (ISO), mitigates cognitive deficits in 3xTg Alzheimer’s disease (AD) model mice (Wang et al., 2015), indicating obvious and various manners of neuroprotection. Here, KCNMA1 is linked to early-onset autosomal dominant Alzheimer disease.