SELP and neoplasm: On the other hand, differences in surface levels of P-selectin and activated integrin αIIbβ3 (Gutiérrez-Herrero et al., 2012; Gutiérrez-Herrero et al., 2020), both playing a role in platelet-tumor cell interaction (Chen and Geng, 2006; Erpenbeck et al., 2010) and the latter also contributing to TCIPA (Bambace and Holmes, 2011), are likely to be the cause of the antagonistic metastatic potential of tgC3G and C3G-KO platelets.