Furthermore, pathological protein aggregation is a shared hallmark of several neurodegenerative diseases: for instance, β-amyloid peptides and tau in Alzheimer’s disease and transactive response DNA-binding protein 43 (TDP-43) in ALS (Phillip et al., 2015; Jo et al., 2020). The gene discussed is TARDBP; the disease is early-onset autosomal dominant Alzheimer disease.