PAX1 and neoplasm: Recently, a report showed that PAX1 plays a tumor suppressing role by forming a complex with WDR5 and SET1B, leading to increased trimethylation of histone H3, lysine 4 (H3K4me3), thus activates the expression of multiple phosphatases including PTPRR, DUSP1, DUSP5, and DUSP6 in cervical cancer cells (Figure 2), maintaining the homeostasis between kinases and phosphatases in cervical epithelium, revealed a functional relevance of PAX1 in cancer biology (Su et al., 2019).