Moreover, albino Abca4−/− mouse model of inherited macular degeneration exhibits progressive photoreceptor loss beginning at 8 months of age, whereas no photoreceptor death was observed up to 18 months of age in pigmented Abca4−/− mice (Radu et al., 2008; Charbel Issa et al., 2013; Wu et al., 2014). This evidence concerns the gene ABCA4 and macular degeneration.