WNK2 and infection: Mitogen-activated protein kinase (MAPK) signaling cascade consists of extracellular signal-regulated kinases (ERKs), C-Jun N-terminal or stress-activated protein kinases (JNKs/SAPKs), and p38 MAPKs pathways, which and are involved in cellular response to inflammatory cytokines, environmental stress, and pathogenic infection (58, 59).