In this study, we primed MSCs originated from the umbilical cord (UCMSCs) with anti-inflammatory cytokines (transforming growth factor beta - TGFβ and interferon alpha - IFNα) and inflammatory cytokines (including tumor necrosis factor alpha - TNFα), which are linked with osteoarthritis (OA) pathogenesis. The gene discussed is TNF; the disease is osteoarthritis.