GSEA analysis based on KEGG pathways showed that the PTX+CKI group were enriched in T cell-related pathways compared with the PTX group, like T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, natural killer cell mediated cytotoxicity, and PD-L1 expression and PD-1 checkpoint pathway in cancer (Figures 10E, F). This evidence concerns the gene CHKA and cancer.