Compared to DDP and PTX monotherapy, the combination of CKI and DDP/PTX presented a more significant inhibitory effect on tumor growth (DDP+CKI vs. DDP on day 21, P < 0.001, Figure 2E; PTX+CKI vs. PTX on day 21, P = 0.051, Figure 2E; DDP+CKI vs. DDP on day 24, P = 0.068, Figure 2E; PTX+CKI vs. PTX on day 24, P < 0.01, Figure 2F). The gene discussed is CHKA; the disease is neoplasm.