In a recent study, the high expression of COL11A1 was positively correlated with CD4+T and CD8+T cells, tumor-associated macrophages (TAM), neutrophils and dendritic cells in colon adenocarcinoma, while the function of these immune cells in colon adenocarcinoma TME has not been identified (34). This evidence concerns the gene CD4 and colon adenocarcinoma.