Our observation that neutAbs maybe encoded by innate IgM during early SARS-CoV-2 infection (detectable in patients with symptom onset time of less than 40 days) is in line with a previous report demonstrating that neutAbs isolated on days 8–17 and days 34–42 after COVID-19 diagnosis showed 97.2% and 97.0% VH gene germline identities, respectively (36). This evidence concerns the gene CD40LG and COVID-19.