MYD88 and rheumatoid arthritis: Furthermore, microarray analysis of gene expression profiling of the SMGs of 10 weeks old female MyD88-deficient NOD versus NOD mice revealed that MyD88 deficiency mainly led to downregulation of genes that are involved in autoimmune diseases, like SLE and rheumatoid arthritis, as well as IFN-associated immunopathological processes (71).These data suggest that signaling through MyD88 is pivotal for SS development.