TLR9 and sialadenitis: Moreover, administration of chloroquine, which inhibits the activation of endosomal nucleic acid-sensing TLRs (68), in NOD mice starting at 4 weeks of age, abolished the elevated expression of TLR1, TLR2, TLR3, TLR4 and TLR9 and reduced sialadenitis in 16 weeks old mice (69).