Overall, based on the above presented data we can hypothesize that SARS-CoV-2 could be a causative agent for SS, probably through the activation of the TLR7 signaling pathway, since the virus can be detected by TLR7 and TLR7 signaling is essential for the antiviral immune response of the host in COVID-19. Here, TLR7 is linked to synovial sarcoma.