TLR7 and systemic lupus erythematosus: In accordance, overexpression of TLR7 in a non-lupus prone background revealed that a 2-fold increase in TLR7 expression is sufficient for the development of spontaneous SLE in mice, whereas a modest increase of TLR7 expression promotes autoreactive lymphocytes with RNA specificities and proliferation of myeloid cells, while substantial increase of TLR7 expression leads to profound dendritic cell (DC) dysregulation and fatal acute inflammation (46).