IFNA1 and Zika virus infectious disease: Combined with the former findings on specific stimulation of 22-nt vsRNAs at both strands upon ZIKV infection in human neural stem cells (NSCs) and human neural progenitor cells (NPCs) (Table 1, S5) (37, 39, 63), in which the IFN signaling pathway is restricted, the accumulation of 22-nt vsRNAs in IFN-deficient cells is more likely to be induced.