The article published in Stroke analyze the biphasic role of microglia in stroke (37): microglia can play different roles in neuroinflammation by secreting different types of TNF-α through binding to TNFR1 or TNFR2, while microRNAs were found to play a biphasic role in post-stroke inflammation by regulating glial cell expression. This evidence concerns the gene TNF and stroke disorder.