The study published in Journal of Neuroinflammation by Chen, S., et al., in 2017 (35) focused on ischemic stroke caused by elevated Hcy levels, which can effectively inhibit STAT3 phosphorylation by blocking the expression of JAK2/STAT3 signaling pathway as well as reducing the secretion of IL-6 and TNF-α, thereby reducing the occurrence of PSN. This evidence concerns the gene TNF and ischemic stroke.