By synthetically analyzing biological information obtained from the tumor samples, macrophages, MDSC, and activated CD8+ T, effector memory CD4+ and CD8+ T, CD56dim natural killer, regulatory T, T follicular helper, and activated B cells were significantly higher in high aggressive group (Puget grade 2, n = 4) compared to low aggressive group (Puget grade 0, n = 3), and most of these immune cells can generate IL-1α and IL-6 (37).We, therefore, hypothesized that the expression of these inflammatory cytokines was increased in PCP tumors, especially Puget grade 2. Here, IL1A is linked to neoplasm.