In a mouse model of SS with enlarged salivary glands: Th1 cell increased and Th2 cells either could not be detected or were present only in low amounts.IFN-γ induced CXCL10 and CXCL9 may play an important role in the destruction of lacrimal and salivary glands. The gene discussed is CXCL9; the disease is synovial sarcoma.