Generally, the number of CD8+ Tregs cells are undetectable or slightly reduced in the peripheral blood of SS, suggesting that it is inversely proportional to disease activity, and there are also large numbers of IFN-γ and CD8+ Tregs in the lacrimal gland, that inactivate dendritic cells and thereby alleviate SS manifestations (76). Here, IFNG is linked to synovial sarcoma.