have demonstrated that prolactin alters B cell development and maturation, causing a decrease in the number of transitional B cells and an increase in the number of mature follicular and marginal zone B cells, which breaks B cell tolerance and generates a lupus-like phenotype in non-susceptible mice with a significant increase in serum anti-DNA antibody titers and IgG deposits in the glomeruli (69). This evidence concerns the gene PRL and systemic lupus erythematosus.