GFAP and vascular disorder: Overall, while PLX5622 treatment and microglia ablation of GFAP-IL6 and GFAP-IFN mice resulted in enhanced tissue destruction and calcification, as well as increased incidence of death in GFAP-IFN mice, the histopathological changes demonstrate there were no overt cellular changes consistent with exaggerated astrocytopathy, vasculopathy, neurodegeneration or immune cell infiltration.