In addition, the implemented pipeline of unbiased analyses, combined with the comparison with 3 control groups, allowed to elucidate how some of the previously reported type 1 diabetes-related immune alterations, such as a reduction of EM CD8 T (8) and CD56dim NK cells (44), are rather markers shared with other autoimmune diseases, or are not selectively altered in type 1 diabetes, as in the case of TR3-56 cells (25). The gene discussed is CD8A; the disease is type 1 diabetes mellitus.