Then, we tested whether, in newly diagnosed T1D patients, the following variables could affect the variance of the circulating immunome: age, sex, BMI percentile, type of Aab, white blood cell count, number of lymphocytes, monocytes and neutrophils, presence of diabetic ketoacidosis (DKA), family history of type 1 diabetes or other autoimmune diseases and presence of HLA-DR3 and/or DR4. This evidence concerns the gene TNFRSF10A and autoimmune disease.