The strain activates intestinal CD103+ DCs through the TLR2/MyD88 pathway to generate IL-10 and induce IL-10-secreting type 1 regulatory T cells in the colon, which in turn induces IL-10 and TGF-β, weakening Th1 and Th2 cells function and ameliorating the colitis (71). Here, IL10 is linked to colitis.