CRC not only mutates in well-known tumor-related genes (such as APC, TP53, KRAS, PIK3CA, SMAD4) but also mutates in other genes, including SMAD2, CTNNB1, FAM123B, SOX9, ARID1A, etc. (79, 80). The gene discussed is AMER1; the disease is colorectal carcinoma.