The secretion of TNF-α, IFN-γ, IL-6, and other cytokines by CD4+ T cells can change the TME (64, 65), induce the local invasion of T lymphocytes into the tumor (66), inhibit the synthesis of DNA and RNA of tumor cells, and thus, induce the apoptosis of tumor cells (65). The gene discussed is IL6; the disease is neoplasm.