CD274 and posterior cortical atrophy: Although studies found that high expression of PD-L1, another biomarker of ICI response, was associated with a variety of clinical parameters, such as proliferation (Ki-67), Gleason Score, and androgen receptor expression (55), and was an independent biomarker in the prognosis of high-risk PCa patients who received adjuvant hormonal therapy after radical prostatectomy (56), the results of relevant clinical trials were unsatisfactory probably due to the tumor immunosuppressive microenvironment.