TRPM8 and colorectal carcinoma: Previous studies revealed that TRPC1 (35), TRPV6 (36, 37), and TRPM8 (38) were upregulated in CRC tissues compared with normal mucosa, whereas TRPV3 (39), TRPV4 (40), TRPV5 (39), TRPM6 (41), and TRPC6 (39) were downregulated in CRC tissues.