The enrichment of DEGs in each cell type in pathways involved in autophagy, apoptosis, ferroptosis and inflammatory bowel disease (Figure 5C), and in particular, radiation-specific CD8+ T cells activated the iron death pathway (Figure 5D), and these results drew our attention to our hypothesis that activation of radiation-specific CD8+ T cells by RT mediates iron death in intestinal epithelial cells. The gene discussed is CD8A; the disease is inflammatory bowel disease.