In the present study, we identified DEGs between IDH1 MUT and IDH1 WT GBM in several datasets, and confirmed six prognostic related GRGs which were significantly correlated with prognosis including CLEC5A, TNFAIP6, PLCB1, MAPK8, TMBIM1, and LDHA. The gene discussed is TNFAIP6; the disease is glioblastoma.