In the present study, we identified DEGs between IDH1 MUT and IDH1 WT GBM in several datasets, and confirmed six prognostic related GRGs which were significantly correlated with prognosis including CLEC5A, TNFAIP6, PLCB1, MAPK8, TMBIM1, and LDHA. Here, MAPK8 is linked to glioblastoma.